It looks like others have had this problem in the past, but there has been no solution posted that I can find. We are running Windows 7 Pro 64-bit, Adobe Acrobat Pro 10.1, using Kodak i40 scanners. When attempting to scan to pdf, the scan comes up on the screen, no problem. However you try to Save/Save As/Open...the menu flashes for a second and goes away. The only workaround we've been able to figure out is to email the scan
http://forums.adobe.com/thread/781018
http://forums.adobe.com/message/3909137
Additional information from one of the users:
When I open Adobe Acrobat Pro and launch a scan (Create | PDF from Scanner | Autodetect Color Mode) it scans the document and displays the results on screen. However, I can’t save the document at that point. Save, Save As, or Open all just flash the application window. At that point, even if I close the scanned PDF, I can’t click on the Open button or Open from the menus… just flashes the application window… doesn’t do anything. If I open Adobe Acrobat Pro and click on the Open button or Open from the File menu, the appropriate dialog window shows up. If I then close the window (without doing anything) and launch a scan, as indicated above, it creates the scan and I can save it as needed and/or click on the Open button. Something with accessing the Open dialog before scanning a document seems to do the trick. Not sure if it is just a matter of setting a default working location? (If it helps, when the Open dialog is displayed it is in the Libraries\Documents directory.)